| Data | In casa | Ospite | Risultato |
|---|---|---|---|
| 26/04/25 20.30 | Toronto FC | New York City FC | -:- |
| 26/04/25 20.30 | Cincinnati FC | Sporting Kansas City | -:- |
| 26/04/25 22.30 | Philadelphia Union | D.C. United | -:- |
| 26/04/25 22.30 | New York Red Bulls | CF Montreal | -:- |
| 27/04/25 01.15 | Orlando City | Atlanta United FC | -:- |
| 27/04/25 01.30 | San Diego FC | Real Salt Lake | -:- |
| 27/04/25 01.30 | Columbus Crew | San Jose Earthquakes | -:- |
| 27/04/25 01.30 | Charlotte FC | New England Revolution | -:- |
| 27/04/25 02.30 | Houston Dynamo | Austin FC | -:- |
| 27/04/25 02.30 | Nashville SC | Chicago Fire | -:- |
| 27/04/25 03.30 | Colorado Rapids | Seattle Sounders | -:- |
| 27/04/25 21.00 | Minnesota United FC | Vancouver Whitecaps | -:- |
| 27/04/25 23.00 | Inter Miami CF | FC Dallas | -:- |
| 28/04/25 01.00 | Los Angeles FC | St. Louis City SC | -:- |
| 28/04/25 03.00 | Los Angeles Galaxy | Portland Timbers | -:- |